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Physical Activity May Slow Alzheimer’s Pathology

Staying Active May Slow Key Alzheimer’s Marker, Study Finds

A new study suggests that regular exercise may slow down the rise of a key Alzheimer’s-related protein in the blood—but only up to a certain point.

What the Study Found

Researchers analyzed over 550 older adults (aged 70+) with memory complaints. They tracked their physical activity levels and measured a protein called phosphorylated tau181 (p-tau181), which is linked to Alzheimer’s disease.

• People who exercised more had a slower increase in p-tau181 levels over time compared to those who were inactive.

• Both low and high levels of moderate to vigorous exercise were linked to this benefit.

• However, for people who already had high levels of p-tau181, exercise did not seem to improve cognitive function.

Why This Matters

This study reinforces the idea that staying active is a powerful tool for brain health. While exercise alone may not be a cure for Alzheimer’s, it could help slow down brain changes linked to the disease—especially if started early.

What You Can Do

• Aim for at least 150 minutes of moderate to vigorous exercise per week (like brisk walking, cycling, or dancing).

• Don’t wait—the earlier you build an active lifestyle, the better it may protect your brain.

• Combine exercise with other brain-healthy habits, such as a balanced diet, social engagement, and good sleep.

The Bottom Line

Staying active isn’t just good for your body—it could help protect your brain, too. Even small lifestyle changes can make a big difference over time!

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