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Just 5 Days Overeating Can Rewire Your Brain and Liver

Short-Term Overeating Can Impact Your Brain and Liver—Even If You’re Healthy

We all know that eating too many snacks isn’t great for our health, but a recent study shows that just five days of high-calorie, ultra-processed foods can have surprising and lasting effects—even if you’re young and fit.

Researchers found that after consuming an extra 1500 kcal per day for just five days, healthy young men showed increased fat accumulation in the liver and changes in brain insulin activity—effects that persisted even after returning to a normal diet for a week. Insulin normally helps regulate appetite and metabolism, but the overeating disrupted how insulin signals in the brain, which could potentially set the stage for long-term weight gain and metabolic issues.

Interestingly, brain regions linked to food reward and emotion processing became less sensitive to insulin after overeating, while areas related to punishment became more active. This means that just a few days of indulging in calorie-dense, processed snacks can change how your brain responds to food.

The study highlights that occasional overeating—even without noticeable weight gain—can affect your brain and metabolism in ways that might make it harder to manage your diet later on. So next time you’re tempted to binge on snacks, think about how even short-term choices can impact your health.

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